Pharmacology
Antibody-Drug Conjugate
Also known as: ADC, Immunoconjugate, Antibody-chemotherapy conjugate
Definition
A targeted cancer therapy that combines an antibody (which targets specific cancer cells) with a cytotoxic drug (which kills cells).
Detailed Explanation
ADCs work like 'guided missiles' for cancer treatment. The antibody portion binds to specific proteins on cancer cells, then releases the attached chemotherapy drug directly inside the cell. This targeted approach maximizes cancer cell killing while minimizing damage to healthy cells. Examples include ADCETRIS (targets CD30) and Enhertu (targets HER2).