Targeted Therapy
Antibody-Drug Conjugate
Also known as: ADC, Immunoconjugate
Definition
A targeted therapy consisting of an antibody linked to a cytotoxic drug, delivering chemotherapy directly to cancer cells.
Detailed Explanation
ADCs combine the targeting ability of antibodies with the killing power of chemotherapy. The antibody seeks out specific proteins on cancer cells, binds, gets internalized, and releases the toxic payload inside the cell. Examples include Adcetris (brentuximab vedotin), Kadcyla, Enhertu, and Trodelvy. They cause fewer systemic side effects than traditional chemotherapy.