Biomarkers
c-MET Amplification
Also known as: MET amplification, MET gene amplification, Hepatocyte growth factor receptor amplification
Definition
Overexpression or gene amplification of the c-MET receptor tyrosine kinase, an oncogenic driver found in various cancers that can be targeted therapeutically.
Detailed Explanation
c-MET amplification occurs in ~3-5% of NSCLC and as a resistance mechanism to EGFR inhibitors. MET exon 14 skipping mutations are another MET alteration. Both are targetable with MET inhibitors like capmatinib or tepotinib.