Biomarkers
EGFR Exon 20 Insertion
Also known as: EGFR ex20ins
Definition
A class of EGFR mutations in NSCLC that respond poorly to first- and second-generation TKIs but have dedicated targeted therapies.
Detailed Explanation
Exon 20 insertions account for 4-10% of EGFR mutations. Agents like amivantamab or mobocertinib are designed to target this alteration.