Biomarkers
EGFR Mutation
Also known as: EGFR+, Epidermal growth factor receptor mutation
Definition
A genetic change in the epidermal growth factor receptor gene, commonly found in lung cancer and targetable with specific medications.
Detailed Explanation
EGFR mutations are found in about 10-15% of lung cancers in the US and up to 50% in Asian populations. These mutations cause cells to grow and divide uncontrollably. EGFR-targeted tyrosine kinase inhibitors can block this abnormal growth signal, offering an effective treatment option for EGFR-positive lung cancers.