Biomarkers
HER2-Low Status
Also known as: HER2 1+, HER2 2+ non-amplified
Definition
Tumors with HER2 IHC 1+ or 2+ without gene amplification, newly targetable with certain antibody-drug conjugates.
Detailed Explanation
HER2-low expands eligibility for therapies like Enhertu beyond classic HER2-positive disease, especially in breast cancer.