Biomarkers
IDH1 Mutation
Also known as: Isocitrate dehydrogenase 1 mutation
Definition
A mutation in the IDH1 gene producing oncometabolite 2-HG, found in cholangiocarcinoma and certain gliomas.
Detailed Explanation
IDH1 mutations can be targeted with inhibitors like ivosidenib. Testing guides therapy in cholangiocarcinoma and lower-grade gliomas.