Treatment
Immune-Related Adverse Event
Also known as: irAE, Immune-mediated adverse event, Immunotherapy toxicity
Definition
Side effects caused by immunotherapy when the activated immune system attacks normal organs and tissues.
Detailed Explanation
irAEs occur because checkpoint inhibitors remove brakes on the immune system, which can then attack healthy tissues. Common irAEs include colitis, pneumonitis, hepatitis, thyroiditis, and skin reactions. Most are manageable with corticosteroids or immunosuppressants if caught early. Patients on immunotherapy need regular monitoring of symptoms and lab tests.