Biomarkers
KRAS G12C Mutation
Also known as: KRAS p.G12C, KRAS gly12cys
Definition
A specific KRAS mutation creating a druggable pocket targeted by G12C inhibitors in lung and colorectal cancer.
Detailed Explanation
KRAS G12C occurs in ~13% of NSCLC and a smaller subset of colorectal cancers. Drugs like sotorasib and adagrasib inhibit the mutant protein.