Treatment Approaches
Line of Therapy
Also known as: Treatment line, Line of treatment
Definition
The sequential order of treatments, with first-line being initial therapy and later lines used after progression or intolerance.
Detailed Explanation
First-line therapy is the standard initial treatment based on clinical trial evidence. Second-line is given after first-line fails. Third-line and beyond are for progressive disease. Choice depends on prior therapies, toxicities, performance status, and available options. Some drugs are approved only for specific lines.