Progression-Free Survival
Definition
The length of time during and after treatment that a patient lives with cancer without it getting worse.
Detailed Explanation
PFS is a key endpoint in cancer clinical trials. It measures the time from treatment start until disease progression or death. Longer PFS indicates more effective treatment. However, PFS improvement doesn't always correlate with overall survival benefit, which is why both endpoints are important. Immunotherapy often shows PFS curves that plateau, indicating durable responses.
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