Targeted Therapy
ADC Payload
Also known as: Cytotoxic payload, Warhead
Definition
The cytotoxic drug component of an ADC, typically a very potent chemotherapy agent.
Detailed Explanation
Common payloads include maytansinoids (DM1, DM4), auristatins (MMAE, MMAF), and topoisomerase inhibitors. These drugs are too toxic for systemic use alone but can be safely delivered when attached to targeting antibodies. Payload choice affects the ADC's mechanism of killing and resistance patterns.