Immunotherapy
Bispecific Antibody
Also known as: BiTE, Bispecific T-cell engager
Definition
An engineered antibody that simultaneously binds to two different targets, typically a cancer cell and an immune cell.
Detailed Explanation
Bispecific T-cell engagers (BiTEs) bring T cells directly to cancer cells, forcing an immune response. Examples include blinatumomab for ALL and newer agents for solid tumors. They can cause cytokine release syndrome but are highly effective for certain cancers. Administered as continuous infusions or frequent injections.