Side Effects
Cytokine Release Syndrome
Also known as: CRS, Cytokine storm
Definition
An immune system overreaction that can occur with immunotherapy, causing symptoms like high fever, low blood pressure, and difficulty breathing.
Detailed Explanation
Cytokine release syndrome (CRS) occurs when large numbers of white blood cells release inflammatory cytokines. While more common with CAR T-cell therapy, it can occur with checkpoint inhibitors. Symptoms range from mild flu-like illness to severe, life-threatening complications. Treatment includes supportive care and immunosuppressive medications if severe.