Targeted Therapy
Drug-to-Antibody Ratio
Also known as: DAR, Conjugation ratio
Definition
The average number of drug molecules conjugated to each antibody molecule in an ADC.
Detailed Explanation
DAR typically ranges from 2 to 8. Higher DAR means more drug delivered per binding event but can affect antibody properties (stability, clearance, aggregation). Lower DAR may require more doses but often has better pharmacokinetics. Optimal DAR balances efficacy and safety.