Clinical Endpoints
Duration of Response
Also known as: DOR, Response duration
Definition
Time from initial response until disease progression, measuring how long treatment responses last.
Detailed Explanation
DOR is only calculated for responders (CR + PR). Median DOR tells how durable responses are. Immunotherapy often shows long DOR even if ORR is modest. Important for quality of life and treatment planning. Longer DOR may reduce need for subsequent therapies.