Biomarkers
FGFR Gene Alteration
Also known as: FGFR mutation, FGFR fusion, Fibroblast growth factor receptor alteration
Definition
Mutations, fusions, or amplifications in fibroblast growth factor receptor genes that drive cancer growth and can be targeted with specific inhibitors.
Detailed Explanation
FGFR alterations occur in 5-20% of urothelial cancers, 15-20% of cholangiocarcinomas, and some other cancers. They're actionable mutations with FDA-approved targeted therapies (erdafitinib, pemigatinib). Testing for FGFR is important for treatment selection.