Side Effects
Immune-Related Colitis
Also known as: Checkpoint inhibitor colitis, Immunotherapy-induced colitis
Definition
Inflammation of the colon caused by immunotherapy, presenting with diarrhea, abdominal pain, and sometimes blood in stool.
Detailed Explanation
Immune-related colitis is one of the more common serious side effects of checkpoint inhibitors, occurring in 5-10% of patients. It results from the activated immune system attacking the colon lining. Management includes stopping immunotherapy temporarily, using anti-diarrheal medications, and in severe cases, corticosteroids or other immunosuppressants.