Side Effects
Immune-Related Thyroiditis
Also known as: Checkpoint inhibitor thyroiditis, Immunotherapy-induced thyroid disorder
Definition
Inflammation of the thyroid gland caused by immunotherapy, which can lead to hyperthyroidism or hypothyroidism.
Detailed Explanation
Thyroid dysfunction is one of the most common immune-related adverse events, occurring in 5-10% of patients. It often begins with hyperthyroidism (overactive thyroid) followed by hypothyroidism (underactive thyroid). Symptoms include fatigue, weight changes, and temperature sensitivity. Treatment involves thyroid hormone replacement if hypothyroidism develops.