Cancer Drugs
Kadcyla
Also known as: T-DM1, Trastuzumab emtansine, Ado-trastuzumab emtansine
Definition
Trastuzumab emtansine (T-DM1), an antibody-drug conjugate targeting HER2-positive breast cancer, combining trastuzumab with the chemotherapy agent DM1.
Detailed Explanation
Kadcyla was the first HER2-targeted ADC, delivering chemotherapy directly to HER2-positive cancer cells. While highly effective, it has been largely superseded by Enhertu, which shows superior efficacy with longer progression-free survival.