Targeted Therapy
ADC Linker
Also known as: Chemical linker, Conjugation linker
Definition
The chemical connection between the antibody and drug in an ADC, designed to remain stable in blood but release the drug inside cancer cells.
Detailed Explanation
Linker stability is crucial for ADC efficacy and safety. Cleavable linkers release the payload in response to specific conditions inside tumor cells (pH, enzymes). Non-cleavable linkers require cell internalization and degradation. Linker design affects both efficacy (drug delivery) and toxicity (premature drug release).